Title : In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters.

Pub. Date : 2021 Aug

PMID : 34074714






1 Functional Relationships(s)
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1 The IC50 for inhibition of CYP2C8, CYP2C9, and CYP3A4/5 for verinurad was {greater than or equal to}14.5 microM, and Iu,max/IC50 was <0.02 at the anticipated therapeutic Cmax and therefore was not considered a DDI risk. verinurad cytochrome P450 family 2 subfamily C member 9 Homo sapiens