Title : Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.

Pub. Date : 2021 May 15

PMID : 34063414






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
2 Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
3 The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
4 In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin production is low and Fpn1 protein expression is elevated. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
5 High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
6 High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus