| Protein Name | solute carrier family 40 (iron-regulated transporter), member 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 53945 |
| Gene Symbol | Slc40a1 |
| UniProt | Q9JHI9 (S40A1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
81
Total Number of Articles : 136 |
Description |
solute carrier family 40 (iron-regulated transporter), member 1 |
| Gene Summary |
Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane. Acts upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022] |
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