Pub. Date : 2021 May 15
PMID : 34063414
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 2 | Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 3 | Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 4 | Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 5 | High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 6 | High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 7 | High Fpn1-mediated iron export depletes intracellular iron, causing a paradoxical increase in Dmt1-mediated iron import. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 8 | It was previously established that Dmt1 knock down prevented iron-loading in weanling Hamp (encoding hepcidin) KO mice (modeling type 2B HH). | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 9 | For example, Dmt1 siRNA treatment suppressed duodenal Dmt1 mRNA expression (by ~50%) and reduced serum and liver non-heme iron levels (by ~60% and >85%, respectively). | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 10 | In conclusion, the combinatorial approach of FA-GDLV and Dmt1 siRNA treatment, with dietary iron restriction, mitigated pre-existing iron overload in a murine model of HH. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |