Title : Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway.

Pub. Date : 2021 May 1

PMID : 34062923






3 Functional Relationships(s)
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1 The cells were exposed to OP at 50 microM for 24 h prior to the administration of MG at 300 microM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Pyruvaldehyde NFE2 like bZIP transcription factor 2 Homo sapiens
2 The cells were exposed to OP at 50 microM for 24 h prior to the administration of MG at 300 microM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Pyruvaldehyde NFE2 like bZIP transcription factor 2 Homo sapiens
3 The cells were exposed to OP at 50 microM for 24 h prior to the administration of MG at 300 microM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Pyruvaldehyde NFE2 like bZIP transcription factor 2 Homo sapiens