Pub. Date : 2021 Jun 1
PMID : 34059615
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | Sevoflurane post-treatment decreased G9a and H3K9me2 levels, and G9a level was negatively correlated with NRF2 level. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 4 | NRF2 silencing reversed the alleviation of sevoflurane post-treatment on OGD-induced cell injury. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 5 | CONCLUSIONS Sevoflurane post-treatment promotes NRF2 expression by inhibiting G9a and H3K9me2, thus alleviating HIBI in neonatal rats. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |