Pub. Date : 2022
PMID : 34053427
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (4) Compared with the control group, the Celastrol treatment also reduced the expression of the mTOR signaling pathway related proteins, suggesting that the mTOR signaling pathway may be involved in the process of Celastrol inhibiting the proliferation of the SGC7901/DDP cells and reducing their drug resistance. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | (4) Compared with the control group, the Celastrol treatment also reduced the expression of the mTOR signaling pathway related proteins, suggesting that the mTOR signaling pathway may be involved in the process of Celastrol inhibiting the proliferation of the SGC7901/DDP cells and reducing their drug resistance. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | (4) Compared with the control group, the Celastrol treatment also reduced the expression of the mTOR signaling pathway related proteins, suggesting that the mTOR signaling pathway may be involved in the process of Celastrol inhibiting the proliferation of the SGC7901/DDP cells and reducing their drug resistance. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | (4) Compared with the control group, the Celastrol treatment also reduced the expression of the mTOR signaling pathway related proteins, suggesting that the mTOR signaling pathway may be involved in the process of Celastrol inhibiting the proliferation of the SGC7901/DDP cells and reducing their drug resistance. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | CONCLUSION: Celastrol can inhibit the proliferation of the SGC7901/DDP cells, induce their apoptosis, and reduce the expression of drug resistance genes, probably by inhibiting the expression of the proteins related to the mTOR signaling pathway. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |