Pub. Date : 2021 May 29
PMID : 34052835
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bioinformatic analysis showed that SOAT1-mediated fatty acid storage and CPT1A-mediated fatty acids oxidation (FAO) formed a double-negative feedback loop in HCC. | Fatty Acids | carnitine palmitoyltransferase 1A | Homo sapiens |
| 2 | We verified that SOAT1 inhibition enhanced CPT1A protein, which shuttled the released fatty acids into the mitochondria for oxidation in vivo and in vitro. | Fatty Acids | carnitine palmitoyltransferase 1A | Homo sapiens |
| 3 | Besides, we further confirmed that CPT1A inhibition converted excess fatty acids into lipid drops by SOAT1 in vitro. | Fatty Acids | carnitine palmitoyltransferase 1A | Homo sapiens |