Title : The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p.

Pub. Date : 2021 Oct

PMID : 34052462






3 Functional Relationships(s)
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1 The JAK Inhibitor Tofacitinib Inhibits Structural Damage in Osteoarthritis by Modulating JAK1/TNF-alpha/IL-6 Signaling Through Mir-149-5p. tofacitinib interleukin 6 Homo sapiens
2 Tofacitinib-treated C20A4 and C28/I2 cells had a significantly lower expression of JAK/IL-6/TNF-alpha and an increased level of miR-149-5p. tofacitinib interleukin 6 Homo sapiens
3 Notably, tofacitinib treatment reduced AC hypertrophy and secretion of RANKL and IL-6. tofacitinib interleukin 6 Homo sapiens