Title : Progesterone Suppresses Cholesterol Esterification in APP/PS1 mice and a cell model of Alzheimer's Disease.

Pub. Date : 2021 Aug

PMID : 34044033






2 Functional Relationships(s)
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1 Progesterone decreased the expression of ACAT1, which could be blocked by progesterone receptor membrane component 1 (PGRMC1) inhibitor AG205. Progesterone acetyl-Coenzyme A acetyltransferase 1 Mus musculus
2 The ERK1/2 pathway maybe involved in the progesterone mediated regulation of ACAT1 in AD models, rather than the PI3K/Akt and the P38 MEPK pathways. Progesterone acetyl-Coenzyme A acetyltransferase 1 Mus musculus