Title : Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534.

Pub. Date : 2021 May 26

PMID : 34040108






1 Functional Relationships(s)
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1 JNJ-61803534 inhibited IL-17A production in human CD4+ T cells under Th17 differentiation conditions, but did not inhibit IFNgamma production under Th1 differentiation conditions, and had no impact on in vitro differentiation of regulatory T cells (Treg), nor on the suppressive activity of natural Tregs. jnj-61803534 interleukin 17A Homo sapiens