Title : Novel Pt(IV) complexes to overcome multidrug resistance in gastric cancer by targeting P-glycoprotein.

Pub. Date : 2021 Oct 5

PMID : 34029775






1 Functional Relationships(s)
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1 Detailed mechanisms in SGC-7901/CDDP cells assays revealed that complex 14 efficiently induced apoptosis via down-regulating expression of P-gp for enhanced intracellular uptake of platinum, arrested cells at G2/M phase, induced DNA damage and initiated mitochondrial apoptosis pathway. Platinum ATP binding cassette subfamily B member 1 Homo sapiens