Title : Proteasome Inhibition Suppresses KIT-Independent Gastrointestinal Stromal Tumors Via Targeting Hippo/YAP/Cyclin D1 Signaling.

Pub. Date : 2021

PMID : 34025442






1 Functional Relationships(s)
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1 Treatment with proteasome inhibitor, bortezomib, led to downregulation of cyclin D1 and YAP/TAZ and an increase in the cleaved PARP expression in three KIT-independent GIST cell lines (GIST48B, GIST54, and GIST226). Bortezomib poly(ADP-ribose) polymerase 1 Homo sapiens