Pub. Date : 2021
PMID : 34017439
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine attenuates acute kidney injury in children undergoing congenital heart surgery with cardiopulmonary bypass by inhibiting the TLR3/NF-kappaB signaling pathway. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Compared with the controls, the DMED group had lower levels of NF-kappaB and TLR3 at T2-T4, lower levels of sCr, IL-1beta, and TNF-alpha at T3-T4, and lower incidence of AKI at T3 (all P<=0.01). | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | CONCLUSION: DMED can reduce the risk of AKI in children undergoing CHS with CPB, which may be because DMED can inhibit TLR3/NF-kappaB signaling and its downstream inflammatory mediators. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | CONCLUSION: DMED can reduce the risk of AKI in children undergoing CHS with CPB, which may be because DMED can inhibit TLR3/NF-kappaB signaling and its downstream inflammatory mediators. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |