Title : TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner.

Pub. Date : 2021 Aug

PMID : 34015428






1 Functional Relationships(s)
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1 Single exposure of slice cultures to TLR2 or TLR3 ligands [PGN, poly(I:C)] for 2-3 days induced moderate microglial activation featuring IL-6 and TNF-alpha release and only mild alterations of fast neuronal gamma band oscillations (30-70 Hz) that are fundamental to higher cognitive functions, such as perception, memory and behavior. Poly I-C tumor necrosis factor Rattus norvegicus