Title : Chronic stimulation of group II metabotropic glutamate receptors in the medulla oblongata attenuates hypertension development in spontaneously hypertensive rats.

Pub. Date : 2021

PMID : 34010316






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1 Compared with that in the sham control group, chronic LY379268 application (mGluR2/3 agonist; 0.40 mug/day) to the dorsal medulla oblongata for 6 weeks reduced the progression of hypertension in 6-week-old SHRs as indicated by the 40 mmHg reduction in systolic blood pressure and promoted their parasympathetic nervous activity as evidenced by the heart rate variability. LY 379268 glutamate receptor, metabotropic 2 Mus musculus