Pub. Date : 2021 May
PMID : 34002012
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When cells were treated with metformin (an AMPK activator), the CRBN-induced activation of SMAD3 and upregulation of alpha-SMA and collagen expression were significantly suppressed, suggesting that increased TGF-beta1-induced activation of SMAD3 via CRBN overexpression is associated with AMPKalpha1 inactivation. | Metformin | actin alpha 2, smooth muscle, aorta | Mus musculus |