Title : Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies.

Pub. Date : 2021 May 14

PMID : 33990655






2 Functional Relationships(s)
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1 We finally tested our hypothesis on human Mesenchymal Stromal Cells differentiated to osteocytes and adipocytes confirming the beneficial effect of docosahexaenoic acid (DHA) omega-3 FA during treatment with rosiglitazone, through the down-regulation of adipogenic genes, such as adipsin and FABP4 along the PPARgamma/FABP4 axis, and reducing the capability of osteocytes to switch toward adipogenesis. Docosahexaenoic Acids fatty acid binding protein 4 Homo sapiens
2 We finally tested our hypothesis on human Mesenchymal Stromal Cells differentiated to osteocytes and adipocytes confirming the beneficial effect of docosahexaenoic acid (DHA) omega-3 FA during treatment with rosiglitazone, through the down-regulation of adipogenic genes, such as adipsin and FABP4 along the PPARgamma/FABP4 axis, and reducing the capability of osteocytes to switch toward adipogenesis. Docosahexaenoic Acids fatty acid binding protein 4 Homo sapiens