Pub. Date : 2021 Nov
PMID : 33982799
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NOXA-mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin-treated human acute myeloid leukemia cells. | Daunorubicin | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | DNR-induced apoptosis in U937 cells accompanied by downregulation of MCL1 and BCL2L1, upregulation of Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA), and mitochondrial depolarization. | Daunorubicin | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Restoration of MCL1 or BCL2L1 expression alleviated DNR-induced mitochondrial depolarization and cell death. | Daunorubicin | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Collectively, these results indicate that the upregulation of NOXA expression through the NOX4-ROS-p38 MAPK-GSK3beta-CREB axis results in the degradation of MCL1 and BCL2L1 in DNR-treated U937 and HL-60 cells. | Daunorubicin | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |