Title : ROS-responsive liposomes with NIR light-triggered doxorubicin release for combinatorial therapy of breast cancer.

Pub. Date : 2021 May 11

PMID : 33975609






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 After endocytosis by MDA-MB-231 cells, Lipo/pB-DOX/ICG produced a large amount of ROS for PDT by laser irradiation, and pB-DOX was converted to DOX by ROS for chemotherapy. Indocyanine Green high mobility group AT-hook 2 Homo sapiens
2 Under irradiation at this time point, the tumors in Lipo/pB-DOX/ICG group almost disappeared with 94.9 % tumor growth inhibition, while those in the control groups were only partially inhibited. Indocyanine Green high mobility group AT-hook 2 Homo sapiens
3 CONCLUSIONS: Lipo/pB-DOX/ICG is a novel tool for on-demand drug release at tumor site and also a promising candidate for controllable and accurate combinatorial tumor therapy. Indocyanine Green high mobility group AT-hook 2 Homo sapiens