Title : Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans.

Pub. Date : 2021 Jul

PMID : 33974957






1 Functional Relationships(s)
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1 Genetic analysis using long-lived mutants and knockdown by RNAi revealed that the lifespan-extending effect of phosphatidylethanolamine overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16, a downstream transcription factor known to regulate the expression of many stress-responsive genes. phosphatidylethanolamine Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans