Title : Effects of trans-resveratrol on type 1 diabetes-induced up-regulation of apoptosis and mitogen-activated protein kinase signaling in retinal pigment epithelium of Dark Agouti rats.

Pub. Date : 2021 Aug 5

PMID : 33974882






3 Functional Relationships(s)
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1 In control rats, 5 mg/kg/d trans-resveratrol administration for 30 days increased gene expressions of tumor suppressor protein 53, Bcl2-associated X protein, B-cell lymphoma-2 (Bcl2), Caspase-3 (CASP3), CASP8 and CASP9, p38alphaMAPK, c-Jun N-terminal kinase-1 (JNK1), and extracellular signal-regulated kinase-1 (ERK1). Resveratrol mitogen-activated protein kinase 8 Rattus norvegicus
2 In control rats, 5 mg/kg/d trans-resveratrol administration for 30 days increased gene expressions of tumor suppressor protein 53, Bcl2-associated X protein, B-cell lymphoma-2 (Bcl2), Caspase-3 (CASP3), CASP8 and CASP9, p38alphaMAPK, c-Jun N-terminal kinase-1 (JNK1), and extracellular signal-regulated kinase-1 (ERK1). Resveratrol mitogen-activated protein kinase 8 Rattus norvegicus
3 Trans-resveratrol reversed the inhibited gene expressions of CASP8, p38alphaMAPK, JNK, and ERK1 to normal control levels in diabetic rats. Resveratrol mitogen-activated protein kinase 8 Rattus norvegicus