Pub. Date : 2021
PMID : 33968030
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We then demonstrated that metformin reduced mTORC1 activity in T cells from infected mice, as evidenced by decreased phosphorylation of ribosome protein S6 (p-S6). | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | The inhibitory effects on the mTORC1 signaling by metformin was dependent on the tuberous sclerosis complex 1 (TSC1). | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Together, our results revealed a protective role and therapeutic potential of metformin against liver injury in acute viral hepatitis via modulating effector T cell activation via regulating the mTORC1 pathway and mitochondrial functions. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |