PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33968030-4 2021 We then demonstrated that metformin reduced mTORC1 activity in T cells from infected mice, as evidenced by decreased phosphorylation of ribosome protein S6 (p-S6). Metformin 26-35 CREB regulated transcription coactivator 1 Mus musculus 44-50 33968030-5 2021 The inhibitory effects on the mTORC1 signaling by metformin was dependent on the tuberous sclerosis complex 1 (TSC1). Metformin 50-59 CREB regulated transcription coactivator 1 Mus musculus 30-36 33968030-8 2021 Together, our results revealed a protective role and therapeutic potential of metformin against liver injury in acute viral hepatitis via modulating effector T cell activation via regulating the mTORC1 pathway and mitochondrial functions. Metformin 78-87 CREB regulated transcription coactivator 1 Mus musculus 195-201