Title : Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells.

Pub. Date : 2021 May 8

PMID : 33966040






3 Functional Relationships(s)
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1 The objective of this study was to determine whether autophagy was induced by inhibition of the Shh pathway and could negatively regulate GANT61-induced apoptosis. GANT 61 sonic hedgehog signaling molecule Homo sapiens
2 Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 induced autophagy in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines; whereas Gli1 overexpression suppressed autophagy. GANT 61 sonic hedgehog signaling molecule Homo sapiens
3 Our study has shown that inhibition of the Shh pathway induces autophagy by activating TAK1, whereas autophagy in turn suppresses GANT61-induced apoptosis. GANT 61 sonic hedgehog signaling molecule Homo sapiens