PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33966040-3 2021 The objective of this study was to determine whether autophagy was induced by inhibition of the Shh pathway and could negatively regulate GANT61-induced apoptosis. GANT 61 138-144 sonic hedgehog signaling molecule Homo sapiens 96-99 33966040-4 2021 Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 induced autophagy in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines; whereas Gli1 overexpression suppressed autophagy. GANT 61 86-92 sonic hedgehog signaling molecule Homo sapiens 38-41 33966040-8 2021 Our study has shown that inhibition of the Shh pathway induces autophagy by activating TAK1, whereas autophagy in turn suppresses GANT61-induced apoptosis. GANT 61 130-136 sonic hedgehog signaling molecule Homo sapiens 43-46