Pub. Date : 2021 Jul 15
PMID : 33965372
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Downregulated expression of intestinal P-glycoprotein in rats with cisplatin-induced acute kidney injury causes amplification of its transport capacity to maintain "gatekeeper" function. | Cisplatin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | This study aimed to investigate the modulation of the expression/function of intestinal efflux transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp), in CDDP-induced AKI rats. | Cisplatin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | This study aimed to investigate the modulation of the expression/function of intestinal efflux transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp), in CDDP-induced AKI rats. | Cisplatin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 4 | On day 3 after the intraperitoneal administration of CDDP (5 mg/kg) to rats, the expression levels of P-gp and Bcrp were compared with those of normal rats. | Cisplatin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 5 | In the CDDP-induced AKI rats, P-gp expression in the ileum was markedly decreased to approximately 38% of that in the normal rats. | Cisplatin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 6 | In conclusion, our results suggested that P-gp expression is downregulated in rats with CDDP-induced AKI but that P-gp maintains its potency as a "gatekeeper" against the absorption of xenobiotics by amplifying its individual transport capacity under these conditions. | Cisplatin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |