Title : Novel 4-(piperazin-1-yl)quinolin-2(1H)-one bearing thiazoles with antiproliferative activity through VEGFR-2-TK inhibition.

Pub. Date : 2021 Jun 15

PMID : 33962153






1 Functional Relationships(s)
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1 In a similar manner to Sorafenib, docking of target compounds with VEGFR-2 protein 4ASD showed HB with Cys919 in hinge region of enzyme and HB with both Glu885 and Asp1046 in gate area. Sorafenib kinase insert domain receptor Homo sapiens