Title : Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.

Pub. Date : 2021 Oct

PMID : 33934381






2 Functional Relationships(s)
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Protein Name
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1 SENP2 interacted with PPARalpha and deSUMOylated it, thereby promoting ubiquitylation and subsequent degradation of PPARalpha, which in turn inhibited FGF21 expression and fatty acid oxidation. Fatty Acids peroxisome proliferator activated receptor alpha Mus musculus
2 SENP2 interacted with PPARalpha and deSUMOylated it, thereby promoting ubiquitylation and subsequent degradation of PPARalpha, which in turn inhibited FGF21 expression and fatty acid oxidation. Fatty Acids peroxisome proliferator activated receptor alpha Mus musculus