Title : Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus.

Pub. Date : 2021

PMID : 33928103






1 Functional Relationships(s)
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1 Positive allosteric modulators (PAM) are pharmacological agents that inhibit desensitization of the nicotinic acetylcholine receptor (alpha7-nAChR), the main anti-inflammatory feature within the cholinergic anti-inflammatory pathway, and may augment alpha7-dependent cholinergic tone to generate therapeutic benefits in SLE. Acetylcholine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus