Pub. Date : 2021 Apr 10
PMID : 33920149
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relationship between CYP3A5 Polymorphism and Tacrolimus Blood Concentration Changes in Allogeneic Hematopoietic Stem Cell Transplant Recipients during Continuous Infusion. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | A polymorphism in the gene encoding the metabolic enzyme cytochrome P450 family 3 subfamily A member 5 (CYP3A5) is a particularly influential factor in the use of tacrolimus in Japanese patients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | A polymorphism in the gene encoding the metabolic enzyme cytochrome P450 family 3 subfamily A member 5 (CYP3A5) is a particularly influential factor in the use of tacrolimus in Japanese patients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | Those who are homozygotic for the *3 mutation lack CYP3A5 activity, which results in substantial individual differences in tacrolimus metabolism. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | The aim of this study was to analyze the relationship between individual differences in tacrolimus blood concentration changes and CYP3A5 polymorphisms in allogeneic hematopoietic stem cell transplantation recipients during the period of increasing blood concentration of the drug following treatment onset. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 6 | This study reveals the effects of CYP3A5 polymorphism on continuous changes in tacrolimus blood concentration. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |