Title : Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals.

Pub. Date : 2021 Apr 7

PMID : 33916910






2 Functional Relationships(s)
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1 For this, BALB/c mice were injected intraperitoneally with LPS (0.33 mg/kg) and treated with the alpha7 nAChR agonist PNU282987, using different administration protocols. PNU-282987 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Peripheral (intraperitoneal) co-administration of the alpha7 nAChR agonist PNU282987 with LPS, attenuated body weight loss and sickness behavior associated with LPS challenge in adult mice, and reduced microglial activation with suppression of IL-1beta and TNFalpha mRNA levels. PNU-282987 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus