Title : Discovery of a novel RORĪ³ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis.

Pub. Date : 2021 Apr 28

PMID : 33911101






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Topical application of SHR168442 in Vaseline exhibited excellent efficacy in the imiquimod-induced and IL-23-induced psoriasis-like skin inflammation mouse models and correlated with the reduction of Th17 pathway cytokines, IL-6, TNFalpha and IL-17A. Petrolatum interleukin 6 Mus musculus