Pub. Date : 2021 May 27
PMID : 33904834
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Different regulation of IRE1alpha and eIF2alpha pathways by oxygen and insulin in ACH-3P trophoblast model. | Oxygen | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 2 | Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively). | Oxygen | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 3 | Although GRP78 protein remained unaffected, low oxygen (2.5% O2) increased IRE1alpha phosphorylation (+52%; P < 0.05) and XBP1 splicing (1.8-fold change; P <= 0.001) after 24h, while eIF2alpha protein and CHOP expression were downregulated (-28%; P < 0.05 and -24%; P <= 0.001; respectively). | Oxygen | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 4 | Overall, our results suggest that IRE1alpha and eIF2alpha UPR-pathways are differentially regulated by oxygen and insulin in early pregnancy. | Oxygen | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |