| Protein Name | endoplasmic reticulum to nucleus signaling 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2081 |
| Gene Symbol | ERN1 |
| UniProt | O75460 (ERN1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
451
Total Number of Articles : 648 |
Description |
endoplasmic reticulum to nucleus signaling 1 |
| Gene Summary |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017] |
| synonyms |
|
| Properties | |