Pub. Date : 2021 Aug
PMID : 33901627
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C-peptide ameliorates high glucose-induced podocyte dysfunction through the regulation of the Notch and TGF-beta signaling pathways. | Glucose | insulin 2 | Rattus norvegicus |
| 2 | The aim of this study was to investigate the effect of C-peptide on high glucose-induced podocyte dysfunction. | Glucose | insulin 2 | Rattus norvegicus |
| 3 | Based on this background, we determined that the application of C-peptide significantly prevented high glucose-induced podocyte injury by increasing the expression of nephrin and synaptopodin. | Glucose | insulin 2 | Rattus norvegicus |
| 4 | Meanwhile, C-peptide suppressed high glucose-induced epithelial-mesenchymal transition (EMT) and renal fibrosis via decreasing the expression of snail, vimentin, alpha-smooth muscle actin (alpha-SMA) and connective tissue growth factor (CTGF). | Glucose | insulin 2 | Rattus norvegicus |
| 5 | Moreover, the Notch and transforming growth factor-beta (TGF-beta) signaling pathways were activated by high glucose, and treatment with C-peptide down-regulated the expression of the Notch signaling molecules Notch 1 and Jagged 1 and the TGF-beta signaling molecule TGF-beta1. | Glucose | insulin 2 | Rattus norvegicus |