Title : Vortioxetine Derivatives with Amino Acid as Promoiety: Synthesis, Activity, Stability and Preliminary Pharmacokinetic Study.

Pub. Date : 2021 Aug

PMID : 33891948






1 Functional Relationships(s)
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1 Notably, threonine-modified 3f exhibited significantly lower activity to SERT, serine-modified 3e showed the fastest degradation rate in rat plasma, with hydrolysis to an extent of 50% in 10 min, and better pharmacokinetic properties in rat, including Cmax, t1/2, and especially AUC0-t, which was ~3-fold higher relative to the parent compound. Threonine solute carrier family 6 member 4 Rattus norvegicus