Title : Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer.

Pub. Date : 2021 Apr 22

PMID : 33888713






1 Functional Relationships(s)
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1 Indeed, we find that persistent tyrosine phosphorylation of HER3 and PI3K recruitment underlies aberrant PI3K/AKT/mTOR signaling in PIK3CA wild type HNSCCs. Tyrosine mechanistic target of rapamycin kinase Homo sapiens