Title : Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.

Pub. Date : 2021 Jun

PMID : 33881611






1 Functional Relationships(s)
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1 We demonstrate that the pharmacological blockade of APA with its selective inhibitor RB150 restores the density of mature spines and significantly reduced filopodia-like processes in hippocampal organotypic slices cultures virally transduced with the Swedish mutated Abeta-precursor protein (betaAPP). firibastat glutamyl aminopeptidase Homo sapiens