Title : Long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats.

Pub. Date : 2021 Apr 20

PMID : 33880773






6 Functional Relationships(s)
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1 Long-access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. Cocaine solute carrier family 6 member 4 Rattus norvegicus
2 We have previously demonstrated that rats with ablation of the serotonin transporter (SERT-/- rats) show increased cocaine intake reminiscent of compulsivity. Cocaine solute carrier family 6 member 4 Rattus norvegicus
3 We have previously demonstrated that rats with ablation of the serotonin transporter (SERT-/- rats) show increased cocaine intake reminiscent of compulsivity. Cocaine solute carrier family 6 member 4 Rattus norvegicus
4 In cocaine-naive animals, SERT deletion evoked widespread abnormalities in markers of glutamatergic neurotransmission that, overall, indicate a reduction of glutamate signaling. Cocaine solute carrier family 6 member 4 Rattus norvegicus
5 We also found that SERT deletion altered glutamate homeostasis mainly after LgA, but not ShA, to cocaine. Cocaine solute carrier family 6 member 4 Rattus norvegicus
6 CONCLUSION AND IMPLICATIONS: Our findings reveal that SERT deletion may sensitize the glutamatergic synapses of the NAc core to the LgA, but not ShA, intake of cocaine. Cocaine solute carrier family 6 member 4 Rattus norvegicus