Pub. Date : 2021 Jun 1
PMID : 33878302
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The low sensitivity (alpha4)3(beta2)2 (LS) and high sensitivity (alpha4)2(beta2)3 (HS) nAChR isoforms may contribute to a variety of brain functions, pathophysiological processes, and pharmacological effects associated with nicotine use. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | Therefore, these results indicate a more prevalent role of HS alpha4beta2 nAChR isoforms in mediating various behavioral effects associated with nicotine, whereas the LS alpha4beta2 nAChR isoform has a limited role in mediating body temperature and nociceptive responses. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | These findings will facilitate the development of more selective, efficacious, and safe nAChR-based therapeutics for nicotine addiction treatment. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |