Title : Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in an Alzheimer's Disease Mouse Model.

Pub. Date : 2021 Apr 28

PMID : 33852279






1 Functional Relationships(s)
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1 We report here the design and development of the first amyloid-beta (Abeta)-targeted, blood-brain barrier (BBB) penetrable theranostic Gd(DOTA)-cyanine dyad, which was synthesized by the conjugation of Gd(DOTA) complex and carbazole-based cyanine dye by the copper(I)-catalyzed azide-alkyne cycloaddition click reaction for imaging of Abeta in vivo and ex vivo in AD mouse models. Azides amyloid beta (A4) precursor protein Mus musculus