Pub. Date : 2021 Jun
PMID : 33850553
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin prevents PFKFB3-related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | The effects of metformin in AMP-activated protein kinase (AMPK) activation was assessed by mitochondrial complex I activity kits. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | The effects of metformin in AMP-activated protein kinase (AMPK) activation was assessed by mitochondrial complex I activity kits. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Metformin significantly decreased mitochondrial complex I activity and upregulated the expression of p-AMPK/AMPK protein in a concentration-dependent manner. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | However, this inhibitory role of metformin on PFKFB3-meditaed aerobic glycolysis and collagen synthesis was prevented by treatments with 3BDO and compound C, which are specific mTOR activator and AMPK inhibitor, respectively. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | Taken together, the findings from this study suggested that metformin may prevent PFKFB3-associated aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts via regulating the AMPK/mTOR pathway. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |