Title : Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.

Pub. Date : 2021 Apr 12

PMID : 33848478






1 Functional Relationships(s)
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1 In a proof-of-concept study, we combined M6620 (berzosertib), first-in-class ATR inhibitor, and TOP1 inhibitor topotecan in patients with relapsed SCNCs. Topotecan DNA topoisomerase I Homo sapiens