Title : Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects.

Pub. Date : 2021 Aug

PMID : 33822421






1 Functional Relationships(s)
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1 Moreover, HUVECs pretreatment with silibinin reduced TNF-alpha-induced gene expression of the proinflammatory genes IL-6 and MCP-1, as well as of PAI-1, a critical factor in coagulopathy and thrombosis, and of ET-1, a peptide involved in hemostatic vasoconstriction. Silybin interleukin 6 Homo sapiens