Pub. Date : 2021 May 1
PMID : 33813880
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In mice overexpressing peroxisome proliferator activated receptor-alpha in muscle (MCK-PPARalpha), lipid supported mitochondrial respiration, membrane potential (DeltaPsim) and H2O2 production rate (JH2O2) were increased, which coincided with a more oxidized cytosolic redox environment, reduced muscle glucose uptake, and whole-body glucose intolerance despite an increased rate of energy expenditure. | Glucose | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Crossing MCAT (mitochondrial-targeted catalase) with MCK-PPARalpha mice normalized JH2O2 production, redox environment and glucose tolerance, but surprisingly both basal and absolute insulin-stimulated rates of glucose uptake in muscle remained depressed. | Glucose | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Also surprising, when placed on a high fat diet MCK-PPARalpha mice were characterized by much lower whole body, fat and lean mass as well as improved glucose tolerance relative to wild-type mice, providing additional evidence that overexpression of PPARalpha in muscle imposes more extensive metabolic stress than experienced by wild-type mice on a high fat diet. | Glucose | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | Also surprising, when placed on a high fat diet MCK-PPARalpha mice were characterized by much lower whole body, fat and lean mass as well as improved glucose tolerance relative to wild-type mice, providing additional evidence that overexpression of PPARalpha in muscle imposes more extensive metabolic stress than experienced by wild-type mice on a high fat diet. | Glucose | peroxisome proliferator activated receptor alpha | Mus musculus |