Pub. Date : 2021 May 30
PMID : 33813002
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dual role of inositol-requiring enzyme 1alpha (IRE-1alpha) in Cd-induced apoptosis in human renal tubular epithelial cells: endoplasmic reticulum stress and STAT3 signaling activation. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 2 | This study aimed to investigate whether the two enzymatic activities of IRE-1alpha have different effects in its regulation of Cd-induced apoptosis. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 3 | Interestingly, inhibition of IRE-1alpha kinase activity by KIRA6 was more protective against Cd-induced apoptosis than inhibition of its RNase activity by STF-083010. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 4 | Mechanistically, Cd promoted the binding of IRE-1alpha with signal transducer and activator of transcription-3 (STAT3) leading to elevated phosphorylation of STAT3 at Ser727 and thus inactivation of STAT3 signaling, which resulted in aggravation of Cd-induced apoptosis in HK-2 cells. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 5 | Mechanistically, Cd promoted the binding of IRE-1alpha with signal transducer and activator of transcription-3 (STAT3) leading to elevated phosphorylation of STAT3 at Ser727 and thus inactivation of STAT3 signaling, which resulted in aggravation of Cd-induced apoptosis in HK-2 cells. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 6 | Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 7 | Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 8 | Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 9 | Collectively, our findings indicate that IRE-1alpha coordinate ER stress and STAT3 signaling in mediating Cd-induced renal toxicity, suggesting that targeting IRE-1alpha might be a potential therapeutic approach for Cd-induced renal dysfunction and disease. | Cadmium | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |