Title : Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.

Pub. Date : 2021 Jul 15

PMID : 33811899






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity. Silymarin NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA). Silymarin NFE2 like bZIP transcription factor 2 Rattus norvegicus
3 SIGNIFICANCE: CGA, Qt, Q10 and silymarin protect against TAA-induced acute liver toxicity via antioxidant, anti-inflammatory, anti-apoptotic activities and regulating Keap1-Nrf2/HO-1 expression. Silymarin NFE2 like bZIP transcription factor 2 Rattus norvegicus