Title : ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling.

Pub. Date : 2021 May

PMID : 33811702






1 Functional Relationships(s)
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Protein Name
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1 Hyperactivation of PARP1 is known to be a major cause of necrotic cell death by depleting NAD+ /ATP pools during Ca2+ overload which is associated with many ischemic diseases. NAD poly(ADP-ribose) polymerase 1 Homo sapiens