Title : ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling.

Pub. Date : 2021 May

PMID : 33811702

1 Functional Relationships(s)
Compound Name
Protein Name
1 Hyperactivation of PARP1 is known to be a major cause of necrotic cell death by depleting NAD+ /ATP pools during Ca2+ overload which is associated with many ischemic diseases. NAD poly(ADP-ribose) polymerase 1 Homo sapiens