Pub. Date : 2021 Mar 29
PMID : 33805532
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging. | nadide | nicotinamide riboside kinase 2 | Mus musculus |
| 2 | We used bioinformatics to identify the Nmrk2 gene involved in nicotinamide adenine dinucleotde (NAD) coenzyme biosynthesis as activated in different mouse models and in hearts of human patients with DCM while the Nampt gene controlling a parallel pathway is repressed. | nadide | nicotinamide riboside kinase 2 | Mus musculus |
| 3 | Nmrk2-KO mice developed a progressive DCM-like phenotype with aging, associating eccentric remodeling of the left ventricle and a decline in ejection fraction and showed a reduction in myocardial NAD levels at 24 months. | nadide | nicotinamide riboside kinase 2 | Mus musculus |
| 4 | Nmrk2 gene is required to preserve cardiac structure and function, and becomes an important component of the NAD biosynthetic pathways during aging. | nadide | nicotinamide riboside kinase 2 | Mus musculus |